Liquid chromatography-tandem mass spectrometry, commonly abbreviated LC-MS/MS, is an analytical technique that combines the separating power of liquid chromatography with the detection and identification capabilities of two stages of mass spectrometry. A sample is first separated by chromatography into its component…
Liquid chromatography-tandem mass spectrometry, commonly abbreviated LC-MS/MS, is an analytical technique that combines the separating power of liquid chromatography with the detection and identification capabilities of two stages of mass spectrometry. A sample is first separated by chromatography into its component molecules; selected molecules are then ionized and fragmented, and the resulting fragment masses are measured to confirm identity and quantify concentration with high sensitivity and specificity. The approach is a standard tool in drug and metabolite measurement, bioanalysis for pharmacokinetic and bioequivalence studies, and food and environmental safety testing. Research published in Current Scientific Research demonstrates these applications directly. Examples include a liquid chromatography tandem mass spectrometry method for determining febuxostat in human plasma to support a bioequivalence study, a rapid and sensitive high-performance liquid chromatography/tandem mass spectrometry method for measuring danshensu in rat plasma, and the use of liquid chromatography-mass spectrometry in food safety analysis. Related work discusses proteomic and genomic techniques in medical research where mass-spectrometry-based methods support diagnostics and personalized medicine. This page gathers peer-reviewed, open-access articles relevant to liquid chromatography-tandem mass spectrometry and its analytical applications.
5 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 5 articles above have been cited 95 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Liquid Chromatography-tandem Mass Spectrometry, linking to each citing work.