Research Topic · Peer-Reviewed

Antidepressants

Antidepressants are a class of psychotropic medications used to treat major depressive disorder and a range of related conditions including anxiety disorders, with their primary action being modulation of monoaminergic neurotransmission. Major pharmacological classes include selective serotonin reuptake inhibitors, …

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 30× across the literature 🔖 ISSN 2476-1710 🗓 Reviewed July 2026

Overview

Antidepressants are a class of psychotropic medications used to treat major depressive disorder and a range of related conditions including anxiety disorders, with their primary action being modulation of monoaminergic neurotransmission. Major pharmacological classes include selective serotonin reuptake inhibitors, serotonin-noradrenaline reuptake inhibitors, tricyclic antidepressants, and monoamine oxidase inhibitors, which raise synaptic availability of serotonin, noradrenaline, or dopamine, alongside newer agents acting through glutamatergic mechanisms such as ketamine and other novel compounds. Therapeutic effects typically emerge over weeks, implicating downstream adaptations in receptor sensitivity, neuroplasticity, and the hypothalamic-pituitary-adrenal stress axis rather than acute changes in monoamine levels alone. Clinical use requires attention to efficacy across diagnoses, latency of response, adverse effects, drug interactions, overdose risk, and special populations such as older adults and patients with comorbid medical illness. The subject matter reflected in this journal's peer-reviewed research spans antidepressant treatment of depression in dementia and cognitive impairment, metabolic and pharmacovigilance considerations including overdose-related hospital episodes, ketamine and experimental neuroprotective compounds, and combined pharmacological and psychotherapeutic approaches in depressed patients, including those with cancer-related pain. Antidepressant pharmacology thus sits at the intersection of neuroscience, clinical psychiatry, and pharmacology, central to the evidence-based management of mood disorders.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2016

Depression and Dementia

Volicer LadislavCorresponding author
School of Aging Studies, University of South Florida, Tampa, FL, USA
Exact topic Depression And Therapy Cited by 2 doi:10.14302/issn.2476-1710.jdt-16-1260
2018

Post Mastectomy Pain is No Longer Nightmare

Ali M. Elzohry AlaaCorresponding author
Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University.
Exact topic Family Medicine Cited by 16 doi:10.14302/issn.2640-690X.jfm-17-1900

How this research is being cited

The 12 articles above have been cited 30 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Antidepressants, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Depression And Therapy (ISSN 2476-1710).

Journal editorial board
Ladislav Volicer · United States Roberto Maniglio · Italy

This page summarises published research for orientation; it is not medical or professional advice.