Aplastic anemia is a bone marrow failure syndrome characterized by pancytopenia, a reduction in red cells, white cells, and platelets, arising from the destruction or depletion of hematopoietic stem and progenitor cells and replacement of cellular marrow by fat. The resulting deficiencies produce fatigue and pallor …
Aplastic anemia is a bone marrow failure syndrome characterized by pancytopenia, a reduction in red cells, white cells, and platelets, arising from the destruction or depletion of hematopoietic stem and progenitor cells and replacement of cellular marrow by fat. The resulting deficiencies produce fatigue and pallor from anemia, increased susceptibility to infection from neutropenia, and bleeding tendency from thrombocytopenia. The condition may be acquired or inherited; acquired forms are frequently immune-mediated, in which cytotoxic T-lymphocyte attack on hematopoietic stem cells suppresses marrow function, and can be triggered by drugs, toxins, viral infection, or autoimmune processes, while inherited bone marrow failure disorders arise from defined genetic defects. Diagnosis requires demonstration of peripheral cytopenias together with a hypocellular bone marrow and exclusion of other causes of marrow failure, including infiltrative and dysplastic disorders. Management depends on severity and patient factors and centers on immunosuppressive therapy and allogeneic hematopoietic stem cell transplantation, with transfusion support and infection prophylaxis as adjuncts; related immune cytopenias such as immune thrombocytopenia share features of immune-mediated peripheral and marrow dysfunction. The journal publishes peer-reviewed research in hematology and oncology, including bone marrow failure, immune-mediated cytopenias, transplantation, and the diagnosis and treatment of disorders of hematopoiesis.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 41 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Aplastic Anemia, linking to each citing work.