Autoimmune disorders arise when immunological self-tolerance breaks down and the immune system directs effector responses against the host's own tissues. Clinically synonymous with autoimmune diseases, the term emphasizes the disordered regulation that permits autoreactive lymphocytes and pathogenic autoantibodies t…
Autoimmune disorders arise when immunological self-tolerance breaks down and the immune system directs effector responses against the host's own tissues. Clinically synonymous with autoimmune diseases, the term emphasizes the disordered regulation that permits autoreactive lymphocytes and pathogenic autoantibodies to persist and cause harm. Loss of tolerance results from failures of central and peripheral checkpoints that normally delete or restrain self-reactive cells, allowing immune attack on specific self-antigens. The resulting conditions present in two broad patterns: organ-specific disorders that target a single tissue or endocrine gland, and systemic disorders with widespread involvement. Several disorders co-occur, as in polyglandular syndromes that combine multiple endocrine deficiencies, while autoantibody-mediated pathology characterizes conditions such as immune thrombocytopenia and various mucocutaneous diseases, including oral lichen planus in which vitamin D status is of interest. Clinical management centers on immunomodulatory strategies that dampen aberrant responses, alongside supportive care, and overlaps with the evaluation of inherited bleeding and coagulation disturbances and psychosomatic dimensions of chronic illness. Diagnosis rests on serological detection of autoantibodies and laboratory characterization of immune function. The journal publishes peer-reviewed research on polyglandular syndromes, immune thrombocytopenia, mucocutaneous autoimmune conditions, and the immunomodulatory and diagnostic considerations that guide care of autoimmune disorders.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 41 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Autoimmune Disorders, linking to each citing work.