Parkinson's disease is a chronic, progressive neurodegenerative disorder caused principally by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of alpha-synuclein aggregates known as Lewy bodies. The resulting dopamine deficiency within the basal ganglia produces the cardin…
Parkinson's disease is a chronic, progressive neurodegenerative disorder caused principally by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of alpha-synuclein aggregates known as Lewy bodies. The resulting dopamine deficiency within the basal ganglia produces the cardinal motor features of bradykinesia, resting tremor, rigidity, and postural instability, alongside non-motor manifestations including cognitive, autonomic, and neuropsychiatric symptoms such as impulse control disorders. The disease is diagnosed clinically and managed through dopaminergic therapy, with advanced cases addressed by device-aided treatments. Research in this area examines deep brain stimulation of the subthalamic nucleus, including segmented-electrode strategies to reduce side effects, and compares continuous infusion therapies such as apomorphine and levodopa-carbidopa formulations. Further work analyses gait and muscle-activation signals, plasma homocysteine and vascular markers, the prevalence of impulse control disorders, and defective molecular pathways and neurotoxicity models relevant to pathogenesis. Allied strands consider music-based and adjunctive approaches in neurology and the contribution of diet and the microbiota. Symptomatic treatment and quality of life remain central, as no disease-modifying cure exists. The journal publishes peer-reviewed research on Parkinson's disease, including deep brain stimulation, pharmacotherapy, gait analysis, and pathway and neurotoxicity studies.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Parkinson's Disease, linking to each citing work.