Transgenic mice are laboratory mice whose genome has been deliberately altered through the introduction, modification, or deletion of specific genes, making them indispensable models for studying gene function, disease mechanisms, and candidate therapies in a living mammalian system. They are generated by introducin…
Transgenic mice are laboratory mice whose genome has been deliberately altered through the introduction, modification, or deletion of specific genes, making them indispensable models for studying gene function, disease mechanisms, and candidate therapies in a living mammalian system. They are generated by introducing exogenous DNA into the germline—classically through pronuclear microinjection or embryonic stem-cell manipulation—so that the engineered sequence is heritable and expressed in defined tissues. By enabling controlled gain- or loss-of-function, tissue-specific and inducible expression, and the humanization of particular loci, transgenic mice allow investigators to dissect the contribution of individual genes to physiology and pathology and to evaluate interventions before clinical translation. They have transformed biomedical research across immunology, oncology, metabolism, and neuroscience. The peer-reviewed research in this area includes work using transgenic mice and related models, such as analysis of the alveolar macrophage proteome in transgenic mice expressing human surfactant proteins SP-A1 and SP-A2, investigations of adipose-tissue physiology relevant to obesity, perspectives on the scope and future of experimental zoology, and discussion of gene-therapy strategies for heart failure. Recurring themes include the use of genetically defined animals to model human biology, the study of proteomic and physiological consequences of targeted genetic changes, and the role of engineered mice in linking gene function to disease and therapeutic development.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 39 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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