Journal of Spine and Neuroscience
Advancing mechanistic understanding of spinal pathophysiology and neural systems through rigorous open access research
Mechanistic Insights into Spinal and Neural Pathophysiology
The Journal of Spine and Neuroscience (JSN) (ISSN 2694-1201) is an international, peer-reviewed, open access journal dedicated to publishing high-quality research that elucidates the molecular, cellular, and systemic mechanisms underlying spinal and neuroscience disorders. Our focus centers on pathophysiological discovery - how diseases develop, progress, and manifest at the molecular level - rather than clinical treatment protocols.
JSN serves as a vital platform for researchers investigating disease mechanisms, biomarker discovery, molecular pathways, and translational models in spine and neuroscience research. We publish original research articles, comprehensive reviews, and methodological advances that advance mechanistic understanding and enable future therapeutic development by others.
Our journal provides rapid publication timelines, global open access visibility, and rigorous peer review by experts in spinal biomechanics, molecular neuroscience, neurodegeneration pathways, and pathophysiology. We are committed to transparency, reproducibility, and advancing the foundational science that underpins clinical innovation.
Understanding Disease Mechanisms, Not Clinical Practice
JSN is uniquely positioned within the pathophysiology discipline. We prioritize submissions that elucidate how diseases work at the molecular and cellular level, including disease pathway analysis, biomarker identification, pathogenic mechanisms, and experimental disease models. Our journal does not focus on clinical diagnosis protocols, treatment guidelines, patient management strategies, or clinical outcomes - these belong in clinical journals.
Authors should frame their research around mechanistic questions: What molecular pathways drive disc degeneration? How do cellular processes contribute to spinal injury progression? What biomarkers predict neurodegeneration? Which genetic or epigenetic factors influence disease susceptibility?
Disc degeneration pathways, spinal cord injury cascades, inflammatory signaling, extracellular matrix remodeling, and molecular drivers of chronic pain.
Cellular and molecular mechanisms underlying neurodegeneration, protein aggregation, mitochondrial dysfunction, oxidative stress pathways, and synaptic failure.
Neuronal signaling mechanisms, glial cell function, synaptic plasticity, ion channel dynamics, and neurotransmitter systems in health and disease.
Neural development pathways, axonal guidance mechanisms, synaptogenesis, critical period biology, and developmental origins of neurological disorders.
Identification and validation of molecular, genetic, imaging, or biochemical biomarkers for spinal and neural pathology detection, progression monitoring, or mechanistic insight.
Modeling neural systems, network dynamics, computational pathophysiology, bioinformatics approaches to disease mechanisms, and systems biology of spine/neural disorders.
Mechanical loading effects on cellular pathways, mechanotransduction mechanisms, biomechanical contributions to degeneration, and stress-induced molecular responses.
Advanced imaging to visualize pathophysiological processes, structural and functional biomarkers, imaging correlates of molecular pathology, and mechanistic neuroimaging studies.
In vitro, in vivo, and ex vivo models that recapitulate disease mechanisms, validation studies, model characterization, and translational model development.
- Global Open Access Visibility: Immediate worldwide access ensures your mechanistic discoveries reach international research communities without subscription barriers.
- Rapid Publication Timelines: Streamlined peer review and production processes deliver fast publication, typically 4-6 weeks from submission to online availability.
- Expert Pathophysiology Review: Manuscripts are evaluated by specialists in molecular mechanisms, experimental models, or computational approaches. Reviewers evaluate hypothesis clarity, methodological rigor, data interpretation, and mechanistic insights.
- Enhanced Research Impact: Open access format increases citation potential, enables data sharing, and amplifies the influence of mechanistic findings across disciplines.
- Interdisciplinary Collaboration: Connect with molecular biologists, systems neuroscientists, biophysicists, and translational researchers investigating disease mechanisms.
- Rigorous Scientific Standards: Publishing in a peer-reviewed pathophysiology journal validates the quality and reproducibility of your mechanistic research.
- Transparent Review Process: Authors receive constructive, expert feedback that strengthens manuscripts and advances mechanistic understanding.
JSN operates a rigorous peer review system designed to evaluate mechanistic rigor, experimental validity, and scientific contribution. Our review process emphasizes reproducibility, statistical robustness, and mechanistic clarity.
- Initial Editorial Screening: The editorial team assesses scope alignment, focusing on pathophysiological content rather than clinical applications. Manuscripts emphasizing treatment outcomes or clinical practice are redirected.
- Expert Peer Review: Manuscripts are assigned to reviewers with expertise in relevant molecular mechanisms, experimental models, or computational approaches. Reviewers evaluate hypothesis clarity, methodological rigor, data interpretation, and mechanistic insights.
- Author Revisions: Authors receive detailed feedback on experimental design, data presentation, mechanistic interpretation, and reproducibility. Revision opportunities strengthen the scientific contribution.
- Final Decision: Editorial decisions prioritize mechanistic novelty, experimental validity, and contribution to pathophysiological understanding. Accepted articles undergo professional copyediting and production.
- Rapid Online Publication: Upon acceptance, articles are published online within 1-2 weeks, ensuring timely dissemination of mechanistic discoveries.
JSN's Editorial Board comprises internationally recognized experts in molecular neuroscience, spinal biomechanics, neurodegeneration, cellular pathophysiology, and computational modeling. Our editors ensure rigorous evaluation of mechanistic research and maintain the highest scientific standards.
Key Requirements for JSN Submissions:
- Manuscripts must present original mechanistic research not under consideration elsewhere
- Clearly describe pathophysiological questions, experimental design, molecular/cellular methods, and mechanistic interpretations
- Include comprehensive methodology sections enabling reproducibility
- Provide detailed statistical analysis and data availability statements
- Follow ethical guidelines for animal or human tissue research with appropriate approvals
- Supply high-quality figures, tables, and supplementary data supporting mechanistic conclusions
- Adhere to JSN formatting and citation requirements detailed in our author guidelines
Submit Your Mechanistic Research to JSN
Join the global community of researchers advancing pathophysiological understanding of spinal and neural disorders. JSN offers rapid publication, expert review, and open access dissemination for high-quality mechanistic research.
