Hashimoto's thyroiditis, also called chronic lymphocytic thyroiditis, is an autoimmune disease in which T-cell-mediated and humoral immunity target the thyroid gland, producing progressive follicular destruction and lymphocytic infiltration. It is the leading cause of hypothyroidism in iodine-sufficient regions and …
Hashimoto's thyroiditis, also called chronic lymphocytic thyroiditis, is an autoimmune disease in which T-cell-mediated and humoral immunity target the thyroid gland, producing progressive follicular destruction and lymphocytic infiltration. It is the leading cause of hypothyroidism in iodine-sufficient regions and is serologically marked by antibodies against thyroid peroxidase (anti-TPO) and thyroglobulin. The histopathology features dense lymphoid infiltrates with germinal center formation and Hürthle (oxyphilic) cell change, and the gland may be diffusely enlarged or atrophic. Clinically, patients can be euthyroid early, then drift toward subclinical and overt hypothyroidism with fatigue, weight gain, cold intolerance, and dyslipidemia; replacement with levothyroxine is the mainstay of treatment. The condition is associated with other organ-specific autoimmune disorders and, importantly, carries an elevated long-term risk of primary thyroid lymphoma and can coexist with extranodal plasma-cell neoplasia, underscoring the value of careful histopathological evaluation of thyroid nodules and diffuse disease. Epidemiological and histopathological studies characterize the diagnostic patterns of thyroid disease across populations, and trace-element and molecular analyses help distinguish benign autoimmune change from malignancy. The journal publishes peer-reviewed research on thyroid autoimmunity, diagnosis, and the malignant transformations that can arise within chronically inflamed thyroid tissue.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 52 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Hashimoto's Thyroiditis, linking to each citing work.