Zeuzera coffea is supposed to be a serious pest of tea and coffee in India (Figure 8), but is more prevalent in Tea and coffee producing countries. It also infests Sandal trees. The destruction is caused by the caterpillars of this pest. The caterpillars bore into the bark of the stem and makes tunnel inside it. It should be determined if the pest is capable of contaminating the coffee beans and causes outbreaks 4.

Coronavirus RNAs were detected in fecal samples and bat guano viruses related to those infecting mammals comprised the third largest group, including members of the viral families Parvoviridae, Circoviridae, Picornaviridae, Adenoviridae, Poxviridae, Astroviridae, and Coronaviridae56. 

Moreover, it was revealed that various SARSr-CoVs capable of using human ACE2 are still circulating among bats in the region of Yunnan Province. Thus, the risk of spillover into people and emergence of a disease similar to SARS is possible. This is particularly important given that the nearest village to the bat cave being surveyed is only 1.1 km away, which indicates a potential risk of exposure to bats for the local residents.

The full-length genomes of 11 newly discovered SARSr-CoV strains, together with other previous findings, reveals that the SARSr-CoVs circulating in a cave inhabited by multiple species of horseshoe bats in Yunnan Province, China are highly diverse in the S gene, ORF3 and ORF8. It is hypothesized that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs. Cell entry studies demonstrated that three newly identified SARSr-CoVs with different S protein sequences are all able to use human ACE2 as the receptor, further exhibiting the close relationship between strains in this cave and SARS-CoV 5.

Coronaviruses are a group of enveloped positive-stranded RNA viruses that consist of four structural proteins including spike (S) glycoprotein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein. Spike glycoprotein is the most important surface protein of coronavirus, which can mediate the entrance to human respiratory epithelial cells by interacting with cell surface receptor angiotensin-converting enzyme 2 (ACE2).

One may speculate that the new virus might exploit cellular attachment-promoting factors with higher efficiency than SARS-CoV to ensure robust infection of ACE2⁺ cells in the upper respiratory tract. It is suggested that the virus might target a similar spectrum of cells as SARS-CoV. In the lung, SARS-CoV infects mainly pneumocytes and macrophages. However, ACE2 expression is not limited to the lung, and extrapulmonary spread of SARS-CoV in ACE2⁺ tissues was observed. The same can be expected for SARS-CoV-2, although affinity of SARS-S and SARS-2-S for ACE2 remains to be compared 7. Also, the idea of considering AT1R blockers angiotensin receptor 1 (AT1R) blockers, such as losartan as tentative treatment for reducing the aggressiveness and mortality from SARS‐CoV‐2 virus, and proposing a research direction based on data mining of clinical patient records for assessing its feasibility is presented 8.

The scientists analyzed the genetic template for spike proteins, armatures on the outside of the virus that it uses to grab and penetrate the outer walls of human and animal cells. More specifically, they focused on two important features of the spike protein: the receptor-binding domain (RBD), a kind of grappling hook that grips onto host cells, and the cleavage site, a molecular can opener that allows the virus to crack open and enter host cells. The scientists found that the RBD portion of the SARS-CoV-2 spike proteins had evolved to effectively target a molecular feature on the outside of human cells called ACE2, a receptor involved in regulating blood pressure. The scientists found that the SARS-CoV-2 backbone mostly resembled related viruses found in bats and pangolins.

Based on their genomic sequencing analysis, it is concluded that the most likely origins for SARS-CoV-2 followed that the virus evolved to its current pathogenic state through natural selection in a non-human host and then jumped to humans. This is how previous coronavirus outbreaks have emerged, with humans contracting the virus after direct exposure to civets (SARS) and camels (MERS). The researchers proposed bats as the most likely reservoir for SARS-CoV-2 as it is very similar to a bat coronavirus. There are no documented cases of direct bat-human transmission, however, suggesting that an intermediate host was likely involved between bats and humans.

In this scenario, both of the distinctive features of SARS-CoV-2's spike protein -- the RBD portion that binds to cells and the cleavage site that opens the virus up -- would have evolved to their current state prior to entering humans. In this case, the current epidemic would probably have emerged rapidly as soon as humans were infected, as the virus would have already evolved the features that make it pathogenic and able to spread between people.

In the other proposed scenario, a non-pathogenic version of the virus jumped from an animal host into humans and then evolved to its current pathogenic state within the human population. For instance, some coronaviruses from pangolins, armadillo-like mammals found in Asia and Africa, have an RBD structure very similar to that of SARS-CoV-2. A coronavirus from a pangolin could possibly have been transmitted to a human, either directly or through an intermediary host such as civets or ferrets.

Then, the other distinct spike protein characteristic of SARS-CoV-2, the cleavage site, could have evolved within a human host, possibly via limited undetected circulation in the human population prior to the beginning of the epidemic. The researchers found that the SARS-CoV-2 cleavage site, appears similar to the cleavage sites of strains of bird flu that has been shown to transmit easily between people. SARS-CoV-2 could have evolved such a virulent cleavage site in human cells and soon kicked off the current epidemic, as the coronavirus would possibly have become far more capable of spreading between people.

If the SARS-CoV-2 entered humans in its current pathogenic form from an animal source, it raises the probability of future outbreaks, as the illness-causing strain of the virus could still be circulating in the animal population and might once again jump into humans. (Summarized and extracted from91011).

Chlorogenic acids are secondary metabolites in diverse plants. Some chlorogenic acids extracted from traditional medicinal plants are known for their healing properties, e.g., against viral infections. Also, green coffee beans are a rich source of chlorogenic acids. Data show that 3,4-O-dicaffeoyl-1,5-γ-quinide is a potential anti-respiratory syncytial virus drug 12. Phenolic acids have recently gained substantial attention due to their various practical, biological and pharmacological effects. Chlorogenic Acid (CGA, 3-CQA) is a most abundant isomer among caffeoylquinic acid isomers (3-, 4-, and 5-CQA), that currently known as 5-CQA as per guidelines of IUPAC. It is one of the most available acids among phenolic acid compounds which can be naturally found in green coffee extracts and tea. CGA is an important and biologically active dietary polyphenol, playing several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension, free radicals scavenger and a central nervous system (CNS) stimulator. In addition, it has been found that CGA could modulate lipid metabolism and glucose in both genetically and healthy metabolic related disorders 13. Japonica Thunb, rich in chlorogenic acid (CHA), is used for viral upper respiratory tract infection treatment caused by influenza virus, parainfluenza virus, and respiratory syncytial virus, etc. in China. It was reported that CHA reduced serum hepatitis B virus level and death rate of influenza virus-infected mice 14.

An animal study found that the intravenous injection of chlorogenic acid (CHA) derived from lonicera inhibited H1N1 and H3N2 influenza by up to 60 percent. Chlorogenic acid is a dietary polyphenol compound that’s produced by many plants, including coffee. Robusta raw coffee beans have up to 10% chlorogenic acid 15. It is shown that quercetin, chlorogenic acid, oleanolic acid, and baicalein present oseltamivir-comparable high binding potentials with neuraminidase and the molecular docking studies identified four potential inhibitors for neuraminidase of H7N9, which might be effective for the drug-resistant mutants 16. Plants rich in chlorogenic acids (CGAs), caffeic acids and their derivatives have been found to exert antiviral effects against influenza virus neuroaminidase. The enzyme inhibition results indicated that chlorogenic acids and selected derivatives, exhibited high activities against NAs. It seems that the catechol group from caffeic acid was important for the activity. Dietary CGA therefore show promise as potential antiviral agents 17. 

The inhibition of neuraminidase activity confirmed chlorogenic acid (CHA) blocked release of newly formed virus particles from infected cells. Thus, CHA has potential utility in the treatment of the influenza virus infection 14.

Chlorogenic acid is one of the representatives that has been proven to have the potential to inhibit both the influenza virus and Streptococcus pneumoniae. The results from binding energy calculation indicated that chlorogenic acid had strong binding potential with neuraminidase. The results predicted a detailed binding mechanism of a potential Streptococcus pneumoniae neuraminidase inhibitor, which will be provide a theoretical basis for the mechanism of new inhibitors 18.

Caffeic acid (CAA) and chlorogenic acid (CHA) are important members of hydroxycinnamic acid with natural antioxidant and cardio-protective properties. Findings from this study shows that CAA and CHA exhibited blood pressure lowering properties and reduced activities of key enzymes linked to the pathogenesis of hypertension in cyclosporine-induced rats, (the activity of the angiotensin-1-converting enzyme (ACE)) 19.

The aim of a rat study was to investigate the modulatory properties of caffeic acid (CA) and chlorogenic acid (CH) on the activity of angiotensin converting enzyme (ACE), purinergic enzyme (PE), and lipid lowering properties in hypercholesterolemic rats. The results showed that CH exhibited stronger ameliorative properties than caffeic acid, based on its effect on the activities of PE, ACE, and atherogenic index. Also, CA exhibited stronger antioxidant properties than CH 20.

It is revealed that there are two different mechanisms, by which the coffee extracts exert inhibitory activities on the virus infection; (1) a direct inactivation of the infectivity of virus particle (i.e., a virucidal activity) and (2) the inhibition of progeny infectious virus formation at the late stage of viral multiplication in the infected cells. Caffeine, but not quinic acid and chlorogenic acid, inhibited the virus multiplication to some extent, but none of them showed the virucidal activity, suggesting that other component(s) in the coffee extracts must play a role in the observed antiviral activity 21. Inhibitor prevents new viral particles (virion) from being released.

According to the above findings, the coffee extracts consumption containing natural protective polyphenol compounds by bats and animals exerts inhibitory activities on the virus infection and these animals remain healthy and resistance to the virus, although are acting as a transmission tools and continue the outbreak.

Coffee cherry tea is a herbal tea made from the dried skins of the coffee fruit (Figure 9). Often it is more than the skins that are used, and include the dried berries (or "cherries") of the coffee plant that remain after the coffee beans have been collected from within. It is also known as cascara, from the Spanish cáscara, meaning "husk".

Coffee cherry tea is a common drink in some coffee-growing nations, notably Bolivia, and, as the variant qishr, in Yemen. Outside of these traditional uses, the coffee fruit is usually considered a wasted byproduct of the coffee-production process.

{Interestingly, Coffee producing and naturally consuming countries have a very low number of morbidity and mortality, despite having a low level of healthy living conditions and a very large number of population. It is assumed that the reason may lie in a reasonable blood level of the polyphenol compounds e.g., Chlorogenic acid (Author assumption)}.

Coffee cherries contain caffeine, as does the tea, though while the tea is popularly understood to have a high level of caffeine, it actually only has about a quarter the caffeine levels of coffee. Cascara is known to be high in antioxidants. The taste of coffee cherry tea is different from coffee, and has been described as somewhat sweet and cherry flavored, surprisingly pleasant.

https://en.wikipedia.org/wiki/Coffee_cherry_tea

It seems that the rate of morbidity and mortality of corona in the countries that freely use Naswār or "chewing tobacco" is fortunately low (Figure 10) and these countries are classified at the bottom row of corona statistical table. The chlorogenic acid in tobacco is reported. Thus, these countries may have a fair amount of chlorogenic acid intake from coffee and tobacco leaves which results to be in an involuntarily state of self- immunity or self- defense against the virus. Sun and heat-dried tobacco leaves, slaked lime, ash from tree bark, and flavoring and coloring agents are mixed together. Water is added and the mixture is rolled into balls.

In Afghanistan, Pakistan, Iran, Kazakhstan, Kyrgyzstan, Russia, Tajikistan, Turkmenistan, and Uzbekistan. Naswar is stuffed in the floor of the mouth under the lower lip, or inside the cheek, for extended periods of time. Usually for from 15 minutes to 30 minutes. It is similar to dipping tobacco and snus. The green powder form is used most frequently. It is made by pouring water into a cement-lined cavity, to which slaked lime (calcium hydroxide) and air-cured, sun-dried, powdered tobacco is added. Indigo is added to the mixture to impart color, and juniper ash may be added as flavoring. Ash is highly alkaline. Currently, the countries of the region freely sell naswar in the markets, usually on trays with cigarettes and sunflower seeds. In 2011 naswar was included in the list of narcotic and psychoactive substances to be controlled in Kazakhstan. On the territory of Russia, naswar is not a traditional product, but it gained popularity especially among teenagers. It was sold in the markets of Moscow and in other cities of the Urals, Volga, and other regions of the country. Its trade was usually conducted on trays with spices. According to the association of tobacco distributors "Grandtabak", in the first half of 2004, Russia's import of naswar or "chewing tobacco" amounted to almost 67 tons (total value of 16,500 US dollars), primarily from Kazakhstan, Kyrgyzstan, and Tajikistan. On 23 February 2013, the Russian State Duma signed a federal law (N 15-ФЗ) which banned both wholesale and retail naswar from 1 June 2013 onward in Russia.

There are two forms of naswar; powder, and a paste cake style mixed with lime. It has a very pungent and powerful smell, resembling that of a fresh bale of coastal hay, and has a subtle flavor as it mixes with the saliva. The nicotine effect can occur within 5 minutes after intake, producing a slight burning sensation on the inner lip and tongue.

Nas: tobacco, ash, cotton or sesame oil, water, and sometimes gum.

Naswar: tobacco, slaked lime, indigo, cardamom, oil, menthol, water.

The major side effect of using naswar is addiction, and it becomes difficult to get rid of it. It is also increasingly known that naswar often causes oral and throat cancer.

https://en.wikipedia.org/wiki/Naswar

Foods contain phytochemicals, including phenolic compounds (mainly as neochlorogenic acids and chlorogenic acids) and sorbitol.

Artichoke, lettuce, sunflower seeds, Apple, quince, cherry, strawberry, potatoes, peach, prune, blueberry, bilberry, mulberry and sweet granadilla, Coffee, tea, and leaves of Hibiscus sabdariffa (Roselle Tea), Tobacco leaves 22.

As of today, there are mounting evidences of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process.

The Hibiscus leaves are a good source of polyphenolic compounds. The major identified compounds include neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, caffeoylshikimic acid and flavonoid compounds such as quercetin, kaempferol and their derivatives.

https://en.wikipedia.org/wiki/Roselle_(plant)

In Dietary supplement: (Figure 11)