This study included 93 patients with a primary discharged diagnosis of COVID-19 pneumonia at World Citi Medical Center from March 01, 2020 to August 31, 2020. Table1 shows the demographic profile of the patients. There were 93 patients with a confirmed diagnosis of COVID-19 Pneumonia, mild to critical. Among these 93 patients, 24 (26%) of which expired and 69 (74%) were recovered and discharged. There was statistical difference between recovered and expired patients in terms of Age (p<0.001), Hypertension (p<0.049), COPD (p<0.022), PIRO score (p<0.001) and PIRO category (p<0.001). Figure 1

The mean age of patients with confirmed COVID-19 pneumonia was 56 years old. There was statistical difference between the mean age of those who expired was 67 and mean age of recovered was 52. In terms of gender, there were more males (56.99%) than females (43.01%) who got infected with COVID-19. Among the co-morbidities in patients with COVID-19 Pneumonia, Hypertension (49.46%) and Diabetes mellitus (29.03%) are the two most common. The two most statistically significant comorbidities that may have contributed to mortality risk are hypertension and COPD with P-value of 0.049 and 0.022, respectively.

Table 2shows the validity of PIRO score to predict in-hospital mortality. Analysis of variance showed that higher levels of PIRO score were significantly associated with higher mortality (p<0.001). Patients with Mild PIRO risk category were 98.65% less likely to expire compared to patients with Very high PIRO risk category (p<0.001, 95% CI (0.0015 – 0.1185)). Patients with High PIRO risk category were 94.47% less likely to expire compared to patients with Very high PIRO risk category (p<0.001, 95% CI (0.0124 – 0.2455)). Patients with Very High PIRO risk category were 44 times more likely to expire compared to patients with Low, Mild and High PIRO risk scoring category (p<0.001, 95% CI (11.738 – 167.09)). There was no mortality recorded among patients in the LOW risk category, and hence cannot be compared.

Table 3shows the sensitivity and specificity of PIRO to predict in-hospital mortality; sensitivity for PIRO score >5 to predict mortality is 83.33%, while specificity for PIRO score <5 to predict that the patient is less likely to expire is 89.86%.

COVID-19 Pneumonia is caused by novel Coronavirus. The clinical features of COVID-19 are varied, ranging from asymptomatic state to acute respiratory distress syndrome and multi organ dysfunction. They are indistinguishable from other respiratory infections. In a subset of patients, by the end of the first week the disease can progress to pneumonia, respiratory failure and death. 4 Originally, PIRO scoring was developed for use in the emergency department (ED) to risk stratify sepsis cases. Eventually PIRO scoring system was used in pneumonia cases to predict its severity. 15

To our knowledge, this is the first study to objectively measure the mortality risk of COVID-19 pneumonia on the basis of risk category of PIRO scoring. Many other models have been developed, some of which are designed to predict mortality. The diversity of scoring tools may pose difficulties for clinicians who are attempting to choose a tool for use in their daily practice. 12 For a tool to be clinically useful, the assessment tool or risk models should be simple, readily measurable, easily accessible, reliable, non-invasive and most of all inexpensive. The simplicity of PIRO score makes it more practical to be used as it is based on four easily assessable components. 10 The validation of PIRO score as an assessment tool for COVID-19 mortality risk among patients with confirmed COVID-19 RT-PCR test aged 19 and above may assist clinicians in managing patients to give proper management in a timely manner.

There were 277 subjects admitted as either COVID-19 Suspect or Confirmed. 159 subjects were excluded for testing negative for COVID-19 RT-PCR and 25 subjects were excluded for having no evidence of pneumonia either by chest radiograph or chest CT-scan. A total of 93 patients met the inclusion criteria and among these patients, 24 (26%) of which expired and 69 (74%) were recovered and discharged. There was statistical difference between recovered and expired patients in terms of Age, Hypertension, COPD, PIRO score and PIRO category.

The mean age of subjects infected was 56.7 and mean age of subjects who expired is 67. Analysis showed that the older the age were significantly associated with higher mortality (p<0.001). Likewise in the study of Farha et al (September 2020), a significant association were found between mortality among COVID-19 infected patients and older age (>65 years vs <65 years) (RR 3.59, 95% CI (1.87-6.90), p<0.001). 18

The two most statistically significant comorbidities that may have contributed to mortality risk are hypertension and COPD with P-value of 0.049 and 0.022, respectively. It is parallel with the recent study of Farha et al (September 2020) shows that a significant association were found between mortality among COVID-19 infected patients and hypertension (RR 2.08, 95% CI (1.79-2.43), p<0.001). 18 Further, the study of Kunzmann (October 2020) showed that COPD has three-fold greater risk of mortality in Severe COVID-19 patients (OR 3.23; 95% CI (1.59-6.57), p <0.05). 19 Stabilizing these comorbidities may alter the clinical outcome of COVID-19 pneumonia, but these claim needs further study.

This tool can be used as an initial risk assessment and stratification that predicts not only the severity of COVID-19 Pneumonia but also in-hospital mortality. As observed in this study s results, subjects with a PIRO score of 5 or more were 27 (29.03%) and 20 (83.33%) of these subjects expired; In contrast, the subjects with a PIRO score of less than 5 were 66 (70.97%) and 62 (89.96%) recovered. Patients with Mild PIRO risk category were 98.65% less likely to expire compared to patients with Very high PIRO risk category (p<0.001, 95% CI (0.0015 - 0.1185)). Patients with High PIRO risk category were 94.47% less likely to expire compared to patients with Very high PIRO risk category (p<0.001, 95% CI (0.0124 - 0.2455)). Patients with Very High PIRO risk category were 44 times more likely to expire compared to patients with Low, Mild and High PIRO risk scoring category (p<0.001, 95% CI (11.738 - 167.09)). There was no mortality recorded among patients in the LOW risk category, and hence cannot be compared.

These results showed that higher levels of PIRO score were significantly associated with higher mortality. (p<0.001) Further, the calculated AUC for predicting in-hospital mortality of COVID-19 Pneumonia is 0.9197, which shows that the tool has excellent discriminative ability. These findings were also parallel with the recent studies, by Pinera et al (2016), 13 which shows that PIRO score had a high discriminatory performance in ICU mortality with an AUC=0.878, as well as that of Esguerra-Llabado et al (2019) 12, which also showed an excellent discriminatory performance in in-hospital mortality with an AUC=0.9313.