I show that the symptom-based causation approach is deeply flawed. The acceptance of symptoms-based causation model in medicine was inevitable before the large organ functional reserves and toxins’ working mechanisms were discovered. Without understanding the roles of organ functional reserves, one would naturally assume that any side effects must appear shortly after an exposure in a manner like “seeing symptoms after exposure”. That is the most probable reason that lead was able to hurt mankind for thousands of years. This flawed approach has dominated all medicine systems for the entire human history, but has been refuted by our model based on post-1980 research discoveries 23, discoveries of organ’s functional reserves 151617, and cellular damage mechanisms 513. It has been found that many biological resources are redundant by huge margins (1 to more than 100 times): the person could survive by using only a 1 unit, but his body may have the ability to provide 100 times of that 18. The problem of the symptom-based side effect evaluation approach is best reflected in lead toxicity. Lead exposure can cause widespread damages in cellular level including changes in gene expression 5 or change gene 101. Since damages take place gradually, the slow changes in cells and tissues cannot instantly depress vital functional capacities because most people have massive surplus vital functional capacities (See Figure 2). As shown in Figure 2, people have great differences in vital functional capacities, as shown in A, B and C. Earliest symptoms of latent side effects occur several years to many decades after exposure, depending on exposure level and personal health. In cases involving exposure to pesticides, the latency period is more than 10 years 97. Symptoms-based prediction would be useful only for people without redundant organ functions. Thus, using distinctive symptoms to find disease causes or causal factors are improper for nearly all culprits. For example, lead damages are not confined to one kind of cells, one single organ or a unique body part, damages must be widespread and systemic 45. The symptom-based side-effect evaluating method cannot survive over a large number of factual findings revealing widespread cellular damages caused by heavy metals 58687, drugs 9, substances 68081, plastics 88, synthetic chemicals 78, unbalanced nutrition 838485, etc. The appearance of the first symptoms are only the earliest signs that tend to appear in the earliest time in a large portion of exposed persons. A generalized observation is that cytotoxicins, carcinogens, neurotoxins, etc. can adversely affect a broad range of cells and tissues. While earliest signs may appear in certain organs or parts, there is no basis to preclude widespread cellular damages in other body parts. The last point is that latent side effects can be inflicted without causing any subjective signs if exposure is chronic and of limited intensity. Evidence in support of this observation is the fact that prescription drugs and industrial chemicals can cause long-term injuries to personal health without causing any sign of discomfort in the early stages of exposures 80828485868788.

I predict that the mRNA vaccines will increase the risks for all kinds of CNS diseases including autism and mental disorders. This prediction is made by regarding all reported CNS problems as the manifestation of vaccines impacts on the CNS. This prediction is based on two propositions: rejecting symptom-based causation approach and disregarding distinctive symptoms. Massive organ surplus functions and the slowness in delivering latent side effects further impair the ability to find vaccines’ long-term side effects. Those two problems are further complicated by a large number of lifestyle and activities factors. The massive number of reported mRNA symptoms indicate that mRNA’s effects are both systemic and non- distinctive. Thus, a sound analysis should not be limited by known symptoms determined by flawed disease classifications. The elevated high incidence of Bell's palsy implies the possibility that mRNA vaccines are able to damage visual nerves, sensory nerves, and any part of the brain. The large number of non-distinctive vaccine symptoms reported in the CDC VAER database or web blogs cannot be “written off” as having nothing to do with vaccines.

The prevalence of autism spectrum disorder (ASD) in children in the U.S. is about three (3) times of the median in most nations 25. I would attribute this high ASD rate to widespread use of vaccines in the U.S. 454647. ASD actually consists of a spectrum of brain disorders that are caused by a large number of causal factors in various combinations. They are influenced by genetic disorders, exposure to toxic substances, parent age, diabetes, bleeding, pre-pregnancy obesity, etc. 2425. Clearly, CNS diseases like ASD cannot be based on the symptoms-based causation model. A retrospective cohort study found that Bell’s palsy and paraesthesia risks increase, and the risks of paraesthesia and inflammatory bowel disease among those vaccinated in the early phase (within 45 days) of the vaccination campaign were significantly increased 47. Massive CNS symptoms from CDC VAER database refute the validity of symptom-based causation model for vaccines. It has been found that Bell's palsy in the vaccine arms is between 3·5-times and 7-times higher than would be expected in the general population 26. This fact also indicates that the vaccines have adverse effects on the brain or nerves or both. Bell's palsy attracted researchers’ attention because it causes obvious signs on face; however, due to random nature of off- target expression, mRNA vaccine-induced damages are expected to affect any part of the brain and nerves although they may not attract attention from researchers. One mechanism of causing ASU is disrupting synapse connections by mRNA vaccines. All reported CNS symptoms, increased risk of Bell's palsy, increased risk of autism (as collaborated by impacts of influenza vaccines), mRNA’s disruption to synapse connections form a concordant evidence for predicting the adverse impacts of mRNA vaccines on the CNS. There is no basis to imagine that all of the massive reported CNS symptoms are harmless and can be fully recovered. Thus, I predict that mRNA vaccine may cause a wide range of CNS diseases including autism spectrum disorders and Bell's palsy. Moreover, human brain has very large functional redundancy. Destroying a few percents of neurons without causing localized tissue damages probably will not be felt, nor detected. Actual damages in most recipients will be felt only after the brain is unable to meet the required function. The increased prevalence of Alzheimer's disease may be partially caused by vaccinations.

Another big problem arises from interactions between vaccines, COVID-19 disease, and other diseases. This problem arises when vaccination is conducted during an active pandemic. A person has a maximum vascular functional capacity, but could survive with only 40% of the maximum, and still survive even at 30% of the maximum 151718. The only organ’s function that can be conveniently monitored is the vascular function. The vascular system’s surplus (unused) functional capacity could range from a few percents to more than 400% (which can be inferred from vascular functions as in 15, 17-18). That implies that personal vascular functional capacities could differ by as much as 100 times between a super strong person (as indicated by D in Figure 2) and a person near death (as indicated by M in Figure 2). Figure 2 shows how infection and vaccination can burden vital organs by both acute injuries and latent injuries (which may reside on the curves). The cytokine storms of the infection and vaccine can add burdens to vital organs. Whether a person can survive from infection/vaccination depends on if the burden from the vaccination/infection is still within the maximum vital functional capacities. If the person has the maximum capacity at D, the person can survive cytokine storms V1 to V4. If the person’s maximum vital functional capacity has been reduced to B due to aging and preexisting diseases, etc, the person can survive from vaccine storms V1 or V2, but cannot survive from vaccination storms V3 or V4. However, vaccination as well as toxic substance can also cause the person to reduce the vital functional capacities by latent side effects. Vaccination-induced inflammation is like disease-induced inflammation, and thus must cause organs to lose functional capacity due to damages that are not reversed. If a person is frequently vaccinated, his vital functional capacities will be slowly reduced from D=Max to C, B, A and M (The Minimum value).

The massive differences in personal vascular systems imply that conclusions from a clinical study cannot be applied to any of real persons. The risk of vaccines on each person must be addressed by focusing on the person’s condition. Each of organ’s functions is maintained by biological resources such as enzymes, DNA molecules, cells, and tissues, etc. A person can live without noticeable problems even if biological resources in support of vital functions have been reduced from 100 to 1.5 on a relative scale. However, the person will experience health problems if any other illnesses, toxic substances, environmental effects, or medical treatments further reduce the biological resources to less than 1 or what is required for maintaining life. No experimental study is able to determine how vaccines, drugs and natural infections consume biological resources in clinics, and the precise manner in which vaccine adverse effects superimpose on the effects of other diseases or toxic substances’ effects. This problem cannot be investigated by a population trial but must be done by theoretical modeling for the person.

If a person receives vaccine injection during the latent period of a unknown SARS-Cov- 2 infection, the vaccine's adverse reaction and COVID-19 disease process will jointly burden all organ functions, particularly the heart function. The worse problem can happen when the peak of vaccine-induced cytokine storm and the perk of COVID-19 cytokine storm happen to overlap, as shown in Figure 3. In this case, the vaccine may cause death of the patient who otherwise would not. The CDC VAER data clearly reveal that many mRNA recipients are COVID-19 positive around the time of receiving vaccine shots. I can see a scenario that viral infection could be very mild from inhaling a small number of SARS-Cov-2 gene copies, and it would take two or more days to develop enough symptoms. In this time window, the viral infection may be slowly activating the immune response against spike protein. Thus, injecting vaccines at this time window could cause the body to produce a large number of spike protein to cause a strong adverse reaction. In the worst scenario, the vaccine-induced reaction peak is in overlap with the virus-caused peak. This could be the worst because vaccine-striking sites are generally different from viral infection sites and thus can jointly raise the overall blood flow resistance; and, in addition, the proceeding viral infection could raise the white blood count in the blood stream and also make the immune system more reactive. Now, the mRNA vaccine is forcefully introduced at relatively high doses in a few seconds, this is not a scenario where the immune system is able to keep the spike protein from entering the body. The vaccination must cause very strong immune response in a very short time. Thus, I must attribute such a death to the vaccine as the primary cause of death while the COVID-19 infection may be secondary or even negligible. Due to smaller particle sizes, mRNA vaccines could reach any part of the body while SARS-Cov-2 virus targets mainly cells with ACE2 receptors 110.

It is reported that, Aix-Marseille University Faculty, Dr. Hervé Seligmann and engineer Haim Yativ, claim that Pfizer's shot causes "mortality hundreds of times greater in young people compared to mortality from coronavirus without the vaccine, and dozens of times more in the elderly, when the documented mortality from coronavirus is in the vicinity of the vaccine dose, thus adding greater mortality from heart attack, stroke, etc." 27. Our theoretic prediction is highly consistent with their findings. Given the very strong peak of the vaccine induced reactions as experienced by a high percent of recipients, one hundred times rise in death rate is completely within my expectation. The real problem is that by using flawed symptom-based research methods, researchers can conveniently “write off” a large number of vaccine-induced deaths.

Heart seems to be the primary target organ injured by mRNA vaccines 2871. After injection, particularly if the injection needle is close the large veins, some mRNA particles must get into the main blood circulation and some of mRNA particles get into heart muscles, where they cause spike protein synthesis. Thus, heart muscles are like accumulators of survival mRNA molecules. They keep producing spike protein until all mRNA particles in blood have been broken down. The extent of damages caused by mRNA vaccines in vaccinated recipients cannot be determined by clinical trials. This mechanism further supports Seligmann and Yativ finding that mRNA vaccines dramatically increased death rate among COVID-19 infected recipients.

In addition, noted symptoms, erythema multiforme, a form of allergic skin reaction, glomerulonephritis or kidney inflammation, and nephrotic syndrome 71 must add burden to the heart. Allergic skin reaction must dramatically raise local blood flow resistance and, similarly, diminished kidney functions can aggravate low-grade systemic inflammation due to accumulated metabolic by-products and thus raise blood pressure. When impacted tissues are widespread, those inflammations can cause heart failure.

The old argument that mRNA vaccine cannot alter cell genetics is not relevant to cancer development speed. Nearly all prior predictions -- in the number hundreds to thousands of drugs and chemicals -- were finally proved to be wrong. The repeated failure implies that wrong results are not isolated incidents, but are due to systematic biases of symptom-based research method, and the poor accuracy of population research model. When a model could not explain so many risk and interference factors, the prediction by using such model is unreliable. The multiple factors model indicates that human body is so complex that many aspects of the body cannot be represented by mathematical models, descriptive models, physical systems, etc. 23. Based on a large number of post-1980 studies, one must find that cancer development speed depends on a large number of factors, particularly, the CNS 29. Cancer risks have been found to rise dramatically in following situations: chronic stress can cause release of excessive stress hormones and impair anti-tumor immunity; DES can elevate the risks of getting many types of cancer by interfering with female hormone metabolisms; glyphosate increases the risks of getting many types of cancer 93949596979899 possibly by impairing hippocampus 90 and impairing the immune system 91; psychotropic drugs can raise many types of cancer risks obviously by interfering with CNS 30. I found overwhelming evidence that CNS controls body's biological processes and tissue integrity 29. In the last fifty years, medical researches have generated a large body of evidence that CNS affects human immune system including anti-tumor immunity. In all those cited cases, increased cancer risks are not realized through genetic mutation, but through compromising the immune system. Since vaccines can impair CNS by overwhelming adverse effects, I predict that vaccines promote cancer growth rates even though they may in some instances cause some types of cancer to self resolve by accident. In addition, altered cell behaviors can often continue to exist as if they were recorded in tissue memory or CNS memory. It is possible that mRNA may cause epigenetic changes, which can remain in the diseased tissue permanently.

Vaccines’ adverse effects through immune overload must be re-investigated in light of the flaws in the research model. Conclusions from population studies must be questioned or even rejected. Their true impacts can be predicted by examining their impacts on the immune cell population and their effects on the vascular system. It is known that B cells are antigens- specific. Thus, generation of excessive B cells (thus a higher plasma concentration) by repeated vaccination must alter this balance. The importance of this balance cannot be appreciated unless we focus on its long-term effects. Vaccination must cause excessive B cells population OR insufficient B cells population for any given disease pathogen. Excessive B cells level must raise systemic blood pressure. By looking at both two limits, there must be an optimum point. I must say that excessive acquired immune responses are not good (even though there are instances that a specific immune response may produce incidental benefits). The existence of those limits are similar to stress hormones and female hormones (as found in DES injury cases).

An excessive number of immune cells in blood is the primary cause of lung tissue damage 31. One big problem is that the capillary pores (~6 µm) are much smaller than most immune cells (10-20 µm). When the body has an excessive number of immune cells, they can dramatically raise local and systemic blood pressures. A big blood pressure spike could result in heart failure, stroke and thrombosis. If the total number of B cells is limited, each type of B cells for a given antigen may be insufficient. In addition, I found that the excessive non- functional B cells and other immune cells must interfere with the functional B cells for fighting a given infection pathogen. From those limits, I concluded that acquired immunity may be intended as the last line of defense when early stage innate defense mechanisms fail to work. Running acquired immune responses at excessively high frequency cannot be a good thing. Non-deadly diseases should be better controlled by innate immunity at the early stage without triggering meaningful B cells differentiation and antibody production. The true adverse impacts of excessive and abusive vaccinations may depend on individual person's conditions and cannot be predicted by extending a population finding 2. Some persons may be able to survive from endless vaccine shots, but some may be unable to survive from one single shot (see discussions for Figure 2). Statistical analysis does funny averaging and produces averaged means that have no bearing on specific persons. The failure to recognize dangers of over reactive immune system should be attributed to the population approach which is incapable of studying immune dynamics for a person.

Past successful vaccinations become incentive to seek vaccines for every infection disease. However, it was suggested in a 2015 research article that vaccination can select for higher virulence 32 and this risk is unique for imperfect vaccines 33. Those findings are consistent with general evolutionary rule 34. The vaccination for the COVID-19 disease is different from other diseases in two aspects. First, SARS-CoV-2 virus is not a genetically stable antigen. By 2021, one leading site has collected more than a million SARS-CoV-2 sequences 35. It can generate one new virus in about 11 to 15 days in an infected person. If we consider the total number of infected persons, the potential number of variants generated in their disease courses is very large; and since most new variants cannot be detected and sequenced, the actual number of viral variants is much larger. A large number of variants could be variants of concern 36. Second, mRNA vaccines cannot produce full immunity mainly due to unique lung structure 37 and temperature effects on the immune system 38. Thus, vaccination with mRNA vaccines must become a selection pressure promoting viral evolution. A population vaccination campaign will promote the virus to generate more virulent variants.

What makes the situation worse is a well known observation that viral infectious power can be increased by variants 39404142. When multiple variants exist in the host, they can become more virulent. It may create a situation that a large number of people carry the virus which is mutating to generate different variants. Many of the infected people, who believe they are disease-free, may get close to each other and thus cross-infect each other. Some of them may get several variants. When multiple variants are present in the same person, they are more virulent. Repeated vaccination by using imperfect vaccines may promote viral evolution. This effect is predicted to be very similar to use of antibiotics: In the early years, antibiotics were very effective for controlling bacteria infection, but now it is more difficult to control bacterial infection 43. In addition, co-infection by influenza viruses may also increase the infectious power of SARS-CoV-2. Thus, reliance on imperfect vaccination will create more obstacles in the long battle against the pandemic. The most recent study has shown that vaccination actually weakens personal anti-viral response even though it also reduces “nominal” death risk from COVID-19 44. Those risks must be considered together with widely used influenza vaccines, which are also imperfect vaccines 454647.

There is a subtle reason to pay attention to genetic mutation which could be caused by mRNA vaccines. Genetic mutation is a very popular natural phenomenon. However, newly created genetic materials in species are controlled by the rule set in evolution. Most of altered genetic materials will disappear upon death of the host. When imperfect vaccines are not available, people must seek more natural measures for survival. There are ample measures 3738 that would improve the population’s ability to weather the disease. However, when the population has heavily relied on mRNA vaccines, they make less efforts to seek natural remedies to improve their innate immunity and to learn basic skills for avoidance. Excessive disruptive interventions may disturb the subtle balance set in evolution.

Attempts to cure diseases by directly interfering with human biological processes have not achieved real success 2. When billions of humans use this unnatural way as the primary anti-pandemic measure, its long-term impacts, if happened at all, could be the worst nightmare in the human history.

mRNA is very unstable and thus requires strict storage and transportation condition. Any stability problems cannot be tolerated for mRNA vaccines. When an mRNA vaccine is in mass production, it would be difficult to maintain required quality 192021. The high stability requirement for mRNA vaccines is similar to other kinds of vaccines. Several incidences were reflected in an influenza vaccination that caused 9 deaths within a day of receiving vaccines. When the mRNA vaccines are used on a large population, it would be hard to avoid storage and transportation problems.

Since mRNA can be degraded by enzymes in blood and tissue, mRNA molecules must be protected by suitable means so that they will not be broken down during their trafficking after injection 5253. mRNA vaccines have strands of mRNA chain inside a special lipid coating. The lipid coating protects the mRNA from being broken down by enzymes in the body. The coating also helps mRNA to enter the dendritic cells and monocytes (macrophages) in the lymph node near the injection site. It is expected that after injection, ongoing generation of vaccine-specific CD4+ T cells occurred only in the vaccine-draining lymph nodes, where detection of mRNA-encoded antigens peaked at 24 hours, whereas the antibody responses were sustained for weeks. Based on those time windows, I must assume that the “disease” course by vaccines is both strong and lasting. To reach the peak in 24 hours, the process must have a very fast responsive character like a rapid infection process. The long lasting nature of antibody implies that vaccinated persons are vulnerable to other disease attacks in the large time windows.

After intramuscular injection is done, the systemic trafficking of mRNA is detected. The mRNA are being destroyed during circulation. A large number of studies investigated the cellular entry of nucleic acids of various types of DNA and RNA 1952. The molecules traveling in blood enter cells by diffusion controlled mechanisms or diverse endocytic processes, often strongly dependent on the respective cell type or species and frequently showed a vesicular localization, i.e., an entrapment in endocytic or lysosomal compartments 555657. Laboratory studies reveal that uptake of naked mRNA is a widespread phenomenon among primary cells and cell lines of diverse types. mRNA uptake depends on primary cells and cell lines, dose, temperature, caveolae or lipid rafts, scavenger-receptor(s), presence of macrophages and dendritic cells, etc. Moreover, different mRNA may use different routes and follow different uptake kinetics. mRNA uptake and expression in the human body is much more efficient than spontaneous uptake by cells in cell culture. Hydrodynamic pressure may force mRNA to enter cells in the case of local injections. A large number of mRNA appears to stay trapped in endosomal vesicles. Those findings show that mRNA uptake cannot be reasonably controlled in the human body.

The systemic distribution and expression of mRNA in different parts of the body could generate systemic cytokines, complement activation, unpredictable or undesirable effects or immune response. Among all studies reflected in the large reviews 192021, no study has explored two fundamental flaws in the mRNA vaccine technologies. First, none of the studies has addressed the deviation in the coating or varying local delivery environment. The average thickness of coatings or their protection times must follow a bell-shaped distribution. The relative protection or thickness of coatings is shown in Figure 4. It is theoretically impossible to achieve the same level of protection against enzymatic degradation because there must be variations among molecules. Even if all particles were coated in the exactly same ways or the delivery system is identical for all mRNA particles, they must have different relative retention or survival times in tissue. After an injection is completed, all mRNA particles are in different tissue environments. I predict that great variations in retention time or traveling distance can be caused by non-identical tissue environments. All cells and tissue environments experienced by different particles must be different due to differences in structural geometries, local blood flow patterns, plasma compositions, locations relative to blood flow, etc. Thus, the coatings cannot be good for all varying conditions in the person. It is expected that a given coating production specification may work well if the vaccine is administrated in one set of conditions but not work well in another set of conditions. It is theoretically impossible to control mRNA’s target delivery even for an imagined person.

A much worst problem is that after a coating specification has been designed for a batch of Mrna vaccine, the coatings cannot be good for all people. The coating or other delivery systems cannot have the magic effects of overcoming all influence factors that must differ from person to person (Figure 5). I predict that enzymatic activities, blood flow properties and local chemical environments, etc. greatly differ due to differences in age, gender, health condition, daily activities, diets, and current environmental factors. This is the same root reason for failure of population medicine. A delivery method that is based on an abstract person cannot be good for all people. Some mRNA particles may be hydrolyzed prematurely, but others may last too long in blood, thus causing off-target expression. Even though intended target is lymph nodes near the injection site, mRNA may enter liver cells, lung cells, brain cells (through the blood brain barrier), spleen cells, nerve cells, etc, purely by chances. mRNA uptake population in a specific tissue or organ depends on injection site, local hydrodynamic pressure, physiological condition, and vascular micro networks. Some vaccinated persons may experience strong adverse reactions while others may experience mild but delayed adverse reactions. The strong support to this prediction is the wide ranges of side effects reported in the CDC VAER database. If the injection needle is close to one or more veins, the mRNA particles can instantly reach the heart.

The risk of COVID-19 mRNA are much bigger than other vaccines because of its smaller sizes. The mRNA is just a sub-unit for encoding the spike protein. The SARS-CoV-2 genome is composed of approximately 30,000 nucleotides, which encodes four structural proteins include spike (S) protein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein 58. Due to the small size, mRNA is much smaller and could more easily penetrate into any types of cells. The whole SARS-Cov-2 virus is much bigger and can enter only a few types of cells. This explains why the number of adverse effects of mRNA vaccines is actually far more than the number of well recognized symptoms of the COVID-19 disease.

Since the start of administrating mRNA vaccines in the U.S. population, recently published articles 205253 have dropped those technical difficulties issues that were well known. None of the well known delivery systems or methods can satisfactorily address all problems revolving around mRNA uptake and off-target expression and accompanied risks to recipients. Those problems are fundamental: the inability to address those problems is same as the inability to cure diseases by using population-based treatments. Population medicine disregards the differences attributable to gender, age, health condition, lifestyle, environment factors, emotional state, etc. Each batch of mRNAs is intended for all people even though they are very different. Uncontrollable systemic distribution and off-target expression must hurt different people in different ways. They may aggregate existing chronic diseases if mRNA enter cells in inflamed tissues and express. In addition, an increased number of immune cells circulate in blood is preferentially caught at the diseased tissue 31.

Based on literature, the consensus is that reverse transcription cannot happen. No one can guarantee that reversed transcription from RNA to DNA will never happen because such a prediction is based on an unrealistic and imagined model, which leaves out thousands of factors from the equation. No one can rule out special conditions which may be created by other substances or another disease agents such as HIV or other retrovirus. It is known that DNA vaccines carry a potential risk of integration into the host genome, which may result in insertional mutation. mRNA could require more steps to achieve it. Once the vaccine mRNA is delivered to the cytosol, its pharmacology is governed by the same complex cellular mechanisms that regulate the stability and translation of endogenous mRNA. I note that many articles argued that mRNA cannot get into cell nuclei. Those predictions are based on abstract models or very limited data. In the real world, persons may carry different disease pathogens that can produce required enzymes and building materials to produce new disease agents or biological systems which can insert a newly created DNA segments into an existing viral genes, body cell DNA chain, bacteria gene which happen to exist in the body, etc. Outcomes from limited animal studies cannot be extended to billions of humans, who can never be under control or may carry various viruses, bacteria, insects, and synthetic compounds. The perceived transportation barrier to cell nuclei is not an absolute one.

To see how unreliable past predictions can be, I urge readers to consider how the genetically modified organism (GMO) raises cancer risks. There is no direct basis to predict that GMO can raise cancer risks for humans. Researchers could not think about omega 6/3 fatty acids ratio before they conducted genetic modification. When cheap GMO feeds with high omega 6/3 fatty acids ratio are widely available, they replaces grass feeds. It is this farming practice that alters omega 6/3 fatty acids ratio in animal meats. It is even more unpredictable that, when most domestic animals such as pigs, chicken, cows, etc. are feed with GMO feeds, this farming practice slowly alters omega 6/3 fatty acids ratio in the Western diet, which ultimately affects human health 838485. No body could foresee how altered genetic compositions in food and feeds will affect cancer risks. Based on repeated failures, I must say that alteration of natural phenomena always pose inherent risks that cannot be predicted reliably due to the overwhelming number of influence factors. Reliable prediction is plausible only if the research model can include all observed and potential influence factors and is sufficiently accurate to characterize each influence factor. There is no possibility for this reductionist science to satisfy both two requirements.

Another problem, which is a big one, is that vaccine-triggered protein synthesis must infringe normal protein synthesis. The two processes compete for same amino acids as building materials, catalyst enzyme, energy, space, etc. The expected mechanisms for interfering normal protein synthesis include:

Compete for ribosomal RNA (rRNA), and transfer RNA (tRNA). The synthesis of mRNA, tRNA, and rRNA is accomplished by an enzyme called RNA polymerase. The presence of spite protein mRNA is expected to have an effect like a product-feedback. Thus, it would inhibit the synthesis of mRNA for normal protein. If vaccine mRNA is self-amplified to generate more mRNA copies, this amplification process interferes with normal mRNA synthesis because they compete for building blocks for mRNA.

Compete for all required enzymes for protein synthesis (e.g., translation) and also compete for the energy which is used to create amino acid chains. For example, spike protein synthesis and normal protein synthesis compete for peptidyl transferase, which is the main enzyme used in translation. The enzyme's activity is to form peptide bonds between adjacent amino acids using tRNAs during translation. The enzyme uses two substrates of which one has the growing peptide chain and the other bears the amino acid that is added to the chain.

Compete for space for protein synthesis. Protein synthesis takes place in cytoplasm. When spike protein synthesis takes place, the synthesis must occupy space and reduces space available for synthesis of structural proteins and catalyst proteins.

Compete for both non-essential and essential amino acids. Amino acids work like building materials for protein. If there are too many spike protein synthesis sites, their availability for normal protein synthesis is reduced. The impact may be on the cells where spite protein is synthesized and found in remote cells. When a large number of cells are involved in spike-protein synthesis, they are predicted to use up amino acids and thus depress amino acids concentrations in blood. It may cause a temporary amino acid shortage.

Altering cell state: whenever a tissue cell has spike protein synthesized, the cell will become a cell for destruction by the immune system.

Predicted impacts include reducing mRNA synthesis for normal proteins, using spaces or sites for synthesis of spike protein, using up amino acids for spike protein synthesis, reducing the amount of structural protein and catalyst proteins for cell normal functions, and marking the cell for T cell attacks. Since mRNA can circulate in blood and can enter into any type of cells, the scope of impacts is widespread: the vaccine affects all vital organs including brain, liver, lungs, kidneys, spleen, all nerves, etc. as long as mRNA vaccines can get into organs or tissue cells. This must be true to near all people under all conditions. It is even possible that mRNA triggered protein synthesis may temporarily deplete amino acids and energy, and thus impairs all protein synthesis processes for making vital structural proteins and enzymes.

All “safe” prediction is based on deeply flawed reductionist model which is based on unreasonable, unrealistic and clearly flawed assumptions: the tissue has unlimited building materials, slowing down normal protein synthesis will not hurt the host person, and amplifying mRNA is very limited or can be controlled and will not disrupt normal RNA synthesis. No study has proved each of the assumptions. Each assumption must be wrong, unrealistic and grossly inaccurate to the scientists with knowledge and training in basics of chemistry and physics. No long term study has been done to understand their side effects. Even if long-term studies have been done, their findings cannot take into account hundreds to thousands of real variables.

One biggest risk is impairment to protein synthesis in the brain and thus mRNA vaccines are particularly harmful to the brain. Establishing proper neuronal connections during brain development and eliciting appropriate responses to environmental stimuli in the adult, requires precisely regulated protein synthesis. Many brain functional mechanisms target mRNA-binding proteins and ribosomal sub-units to regulate protein synthesis initiation. These mechanisms are especially concentrated at synapses, where they act to transform transient electrical signals into lasting functional modifications that are a basis for learning and memory, and misregulated synaptic protein synthesis contributes to several human cognitive changes including addiction, fragile X syndrome, and autism 111. The S1 protein of SARS-CoV-2 can crosses the blood–brain barrier in mice 112. While native mRNA cannot easily cross the brain blood barrier, the lipid coatings may facilitate mRNA to cross the brain blood barrier 113. In addition, mRNA may even interfere with brain blood barrier because carrier protein such as brain-type glucose transporter is synthesized by using mRNA 114. Since mRNA must be present in neurons and brain blood barriers, the presence of foreign mRNA must interfere with all normal protein synthesis in blood brain barrier cells. When mRNA gets into the cells in the blood barrier, it may impair the barrier’s integrity by impairing carrier protein synthesis or cause the cell to be destroyed by the immune system. When mRNA gets into neurons, it interferes with normal protein synthesis in the neurons and thus leaning and memory. Each time when a cell is converted into a spike protein-containing cell, it becomes destruction target of the immune system. Cytotoxic T cells may kill spike protein-expressing brain cells and BBB cells. The damage is hard to repair because neurons in the brain rarely regenerate. In addition, by altering the integrity of the brain blood barrier, the vaccine is predicted to alter material compositions in the blood inside the brain. Vaccine recipients have reported lost memory and dramatically reduced intellectual capacities. The massive number of signs reported in CDC database are consistent with what would be expected from disrupted normal protein synthesis.

Vaccination of pregnant woman with mRNA vaccines may impair fetal brain development, resulting in future mRNA BABIES. Another even bigger risk is mRNA vaccine may irreversibly disrupt vital protein synthesis function. This risk may be seen on a person, whose protein synthesis function is nearly a limited factor due to aging, poor health, preexisting cellular damages, chronic diseases, and inhibitory effects of toxic substances. The mRNA cytokine storm can cause increased stress on all vital organs. By disrupting the normal protein synthesis, the vaccination results in depletion of biological resources (e.g., enzymes, proteins, energy and all other required compounds), which are necessary for sustaining life and restoring organ functions and repairing damages. Those two adverse effects put affected organs or parts in a condition that is unable to resolve vaccine-induced inflammation and damages. This risk is underscored by another known fact: a diseased state is nearly always persistent. For example, obesity cannot be easily corrected; immune responses have lasting memory role 44, changed gene expression in lead poisoning is persistent after removal of lead from the body 5, etc. I reasonably suspect that hijacking the cellular machinery from synthesizing life-sustaining proteins to generating spike proteins is bad innovation. It is unclear whether the normal protein synthesis can be fully restored, but my prediction is negative. Even if the normal protein synthesis function can be fully restored, the combination of vaccine cytokine storm and diminished resource availability for protein synthesis is dangerous to some recipients. This theory can explain why some recipients feel fatigues and lack of energy for extended times while other recipients feel they have become different persons ^{such instances could be tabulated}. It is possible that some people could not restore the normal protein synthesis function.

Clinical trials and controlled studies are good at ascertaining strong effects of any drug or treatment, but cannot detect slowly-delivered long-term effects of anything due to a large number of interference factors. Based on observed case outcomes discussed above 4567891011 and all removed harmful drugs 12, the chance of failure of clinical trials and controlled study is nearly 100%. I could not find a single case where clinical trials correctly predicted future adverse health effects. The failure is deeply rooted in the reductionist model: all models used in studies are unable to include all potential variables 23. The mRNA vaccines are like a super virus with high penetrating power, they are capable of getting to any types of cells except they cannot transmit from human to human. Their short-term benefits are based on the increased immune system’s sensitivity while they have dramatic impacts on the vascular system, the CNS, kidneys, lungs, spleen, liver, etc. Due to their small sizes and high penetration power, they can get into any tissue and are expected to cause a large number of symptoms. I predicted that true adverse impacts on people is 100%.

However, huge vital functional capacities 15161718 (with large surplus functional capacities) in a super majority of people can conceal true adverse effects of the vaccines in the population data. As shown in Figure 2, if the adverse reactions do not depress their vital functional capacities to nearly disability levels, the recipients most likely feel no symptom. The observed “no harm” on those healthy persons thus dilutes their true adverse effects on a small number of vulnerable people to produce the false impression of “no harmful effect”. In addition, as I have shown that vaccines must add burdens to the vascular system and thus increase the chance of death; but due to lack of distinctive symptoms, most vaccine-triggered deaths are routinely improperly attributed to other causes such as COVID-19 infection, other diseases, or natural causes. All deaths caused by disrupted brain functions may be improperly attributed to other causes. If a limited number of mRNA enters the brain or nerve cells, their effects may be not strong enough to impair recipients’ feeling and sensation. That does not mean no alteration has taken place or that alterations can be fully reversed. If vaccine recipients have existing diseases, the vaccines may aggravate them. If adverse effects at disease sites are resolved, the vaccines may cure the diseases as an incidental benefit. If vaccine recipients have previously healed diseases, the vaccines may cause the diseases to relapse (based on self reports). Under influences of a large number of factors and variables, vaccine adverse effects must be manifested as different symptoms. I predict that, after making adjustments to correct research model flaws, both efficacy rate and adverse reaction rate are 100%. However, the long-term adverse effects are not known at both personal levels, population levels, and viral evolution level. At the personal level, vaccines harm the recipients by reducing vital functional capacities while their acute adverse effects may be realized by adding additional burdens onto the vascular system.

In a natural disease course, immunization is acquired after getting a first infection of a particular disease agent. The first infection leaves immunological memory so that when the person is exposed to the same disease agent, the immune response will be much faster and efficient. However, in all natural infection processes, all expected future exposures are always limited to a very limited number of seed pathogens: perhaps one, several, thousands or millions in the worst situation. It can never be in the number like 109 to 1011 from a shot. We also know a similar reason in managing allergic reactions: after a person has become sensitive to a compound, exposure to the compound even at moderate amount must be avoided. Both those two observations tell that after the immune system has been sensitized, exposure to a large number of antigens is a forbidden thing. This rule is set in evolution. The rationale of avoidance of severe sequential exposures can be shown in Figure 6) The Figure shows that the first vaccine shot will generate a small cytokine storm but administrating the second shot must cause much severer reactions. Each cytokine storm can cause acute organ injury. In addition, the first shot or each additional shot is presumed to have latent adverse impacts on organs and thus diminishes organ’s functional reserve. The ability to withstand the vaccine impacts is shown in the green line SM1 and SM2, which is predicted to become smaller and smaller with successive vaccine shots. For those 12 to 39 years old, heart inflammation was 4.4 cases per million first shot but increased to 12.6 cases per million in second shot 28. Those numbers are not based on cellular damages. Successive vaccinations with the same vaccine would progressively reduce the safety margins. While this is not a big risk for healthy persons who have massive vital functional capacities (particularly biological resources), the vaccine could cause expected damages by erratic mRNA particles. Additional booster shots are predicted to pose much bigger risks due to activated immune system. Due to differences in vital functional capacities, and unpredictable acts of mRNA, the amount of permanently lost organ functional capacities cannot be determined. I predict that keeping being vaccinated successively will end with death as a theoretical limit. This prediction can be easily validated by successively vaccinating any laboratory animals. For people with their vascular functions at near disability levels, booster shots could pose much high risk of death.

I also predict that, if booster shot’s cytokine peak and COVID-19-induced peek happen to superimpose, they can dramatically raise blood pressure or burden the kidneys. The total number of mRNA copies delivered in a vaccine shot can be computed. The vaccine cytokine storm is a front-peaked curve while the COVID-19 cytokine storm has a progressively rising curve. The total number and mass of SARS-Cov-2 virions in a real infection can be determined in ballpark 67. Based on those numbers and observed disease progression course, the viral impact curve and the vaccine impact curve must be very different. The vaccine peak could be much larger than COVID-19 peak, as shown in Figure 3. The reason is that more than a billion mRNA particles are injected INSTANTLY to produce spike protein in a very short time, while the virus must slowly gain its population against immune system’s check. I must say that death in such a situation is caused primarily by the vaccine rather than the COVID-19 infection.

In predicting the adverse effects of mRNA vaccines, I must consider past failures in predicting latent side effects for asbestos, lead paint, DES, GMO, Roundup and removed drugs because their failures are rooted in the same model flaws. In each instance, no or little evidence existed for making prediction of future adverse health effects, but final outcomes, which often appeared decades later, are catastrophic to public health. mRNA vaccines have far more bad signs for predicting their bad outcomes. Those signs include well known technical difficulties, poor stability, uncontrollable uptake, off-target expression, interference with normal protein synthesis, and the overwhelming number of reported side reactions. Its central mechanisms are to disrupt or interfere with the vital cell machinery for maintaining life, they are predicted to be more vicious than the virus; and current prediction by other researchers is largely based on abstract model or oversimplified animal models with thousands of real variables being ignored. By using our multiple factors disease causes model and our kinetic analysis, it is absolutely clear that booster shots are not a proper measure for the population.