Research Article
Pages 1–21
Chemoenzymatic Synthesis of Purine Modified 3′-deoxy-D-ribonucleosides and Evaluation of Their Antiproliferative Activity
- Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220084 Minsk, Acad. Kuprevicha 5/2, Belarus
- Institute of Microbiology of National Academy of Sciences of Belarus, 220084 Minsk, Acad. Kuprevicha 2, Belarus
From the abstract
Chemoenzymatic synthesis of a series of purine modified 3′ deoxyribonucleosides was studied from purine derivatives as acceptors and an excess of 3′-deoxyuridine as the donor, prepared by the chemical deamination of 3′-deoxycytidine, using recombinant uridine and purine nucleoside phosphorylases as biocatalysts in enzymatic reactions.