Abstract
Children with complicated Severe Acute Malnutrtion (SAM) admitted to Therapeutic Feeding Center (TFC), and uncomplicated SAM managed in Outpatient Therapeutic Program (OTP).
This study aims to examine the anthropometric differences between SAM admitted to TFC and OTP.
A hospital based case control study conducted in the Therapeutic Feeding Program (TFP) of Al-Sadaka General Teaching hospital, Aden, included complicated (cases) and uncomplicated (control) severely wasted 6-60 month old children admitted between July 2022 to June 2023. The WHO anthropometric calculator was used to assess every child s weight-for-length/height SD and length/height for age SD.
A total of 313 cases and 122 controls were admitted, mean age, weight, length/height, and MUAC among the cases were (13.04±7.34 mo., 5.41±1.33 kg, 68.32±7.10 cm, and 10.57±1.36 cm) respectively; while among the controls were (20.05±12.93 mo., 7.05±1.74 kg, 76.89±10.46 cm, and 11.28±1.11 cm) respectively. Severe wasting by WFL/H < - 3SD z- score seen more among the controls; cases vs controls were (37.0% vs 68.9%). Howevere, the other groups of severity of WFL/H z-score were seen with nearly douple frequencies among the case vs the controls (35.8% vs 18.8% < - 4SD), (14.7 vs 7.4% < - 5SD). Less than - 6SD was seen much more among the cases vs the controls (8.6% vs 1.6%). Less than - 7 SD among the cases was 1.3% and no children belong to this group in the controls.. The majority of the cases belonged to the age group 6-24 months.
Children a dmitted to TFC had severe wasting reaching up to < - 6 and < - 7 SD below the WHO cut-off, WFL/H < - 3SD z-score, and at an early age, with simultaneous presence of severe stunting and low MUAC which denotes high mortality risk.
Author Contributions
Copyright© 2024
H. Al-Sadeeq Aida, et al.
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Introduction
Severe Acute Malnutrition (SAM) among under 5-year-old children is defined by a very low weight-for-length/height, or clinical signs of bilateral pitting oedema, or a very low mid-upper arm circumference. Worldwide, SAM affects an estimated 19 million children under 5 years of age and is estimated to account for approximately 400,000 child deaths each year While requiring nutritional intervention, not all severely malnourished children require hospitalization The early detection of severe wasting and edematous malnutrition and outpatient therapy for these conditions using RUTF forms the cornerstone of modern therapy, and only a small percentage of children develop complications requiring inpatient care Our hypothesis is, that children who develop complications and in need of inpatient care have more severe degrees of wasting, below the cut-offs, compared to those admitted to outpatient care. Therefore, this study aims to examine the anthropometric differences between children admitted in the TFC and the OTP with regards to the extent of severity of severe wasting and to measure the frequency of stunting among these children. Patients and setting: this was a hospital based unmatched case control study conducted in the TFP of Al-Sadaka General Teaching hospital, Aden/Yemen, and included complicated (cases) and uncomplicated (control) severely wasted 6-60 month old children admitted to the TFC and the OPT, respectively, over a period of 1 year between July 2022 to June 2023. Inclusion criteria: Children 06 – 60 months old with severe wasting either by WFL/H < -3SD z- score or mid upper arm circumference (MUAC) < 11.5 cm who admitted to the TFC with complications (cases) and to the OTP without complication (controls) Exclusion criteria: Children beyond the age range, having edema, history of perinatal insult (birth asphyxia/trauma/intraventricular hemorrhage (IVH)/kernicterus etc.), history of neonatal intensive care unit (NICU) admissions in the neonatal period, evolving central nervous system disease, gross malformation or secondary malnutrition were excluded. Data collection: The following data of the first day of admission for all severely wasted children retrived retrospectively from TFC and OTP regestries, in a pre-structured data sheet: Age in months (mo.), gender, weight in kilogram (kg) length/height in centimeters (cm), and MUAC in cm. The WHO anthropometric calculator, age and sex specific, was used to assess every child’s weight-for-length/height (WFL/H) SD z-scores and length/height for age (L/HFA) SD z- scores The statistical analyses were carried with SPSS software (Statistical Package for the Social Sciences, version 24). Numerical data were described as mean ±SD. Frequency tables with percentages were used for categorical variables. A p-value < 0.05 is considered statistically significant.
Results
A total of 313 complicated severely wasted children (cases) were admitted to the TFC, boys (48.9%) and girls (51.1%). Uncomplicated severely wasted children (controls) admitted to the OTP were 122, among them boys (41.8%) and girls (58.2%). Mean age, weight, length/height, and MUAC among the cases were (13.04±7.34 mo., 5.41±1.33 kg, 68.32±7.10 cm, and 10.57±1.36 cm) respectively; while the mean age, weight, length/height, and MUAC among the controls were (20.05±12.93 mo., 7.05±1.74 kg, 76.89±10.46 cm, and MUAC 11.28±1.11 cm) respectively. P value <0.001 presented in Only 4.2% of children belong the age group 25-60 mo. Among the controls, the proportion of children from the three age groups were nearly similar, with 6-12 mo., 13-24 mo, and 25-60 mo. represented 34.4%, 35.2%, and 27.1% respectively. Severe stunting was found among 41.9% of the cases and nearly all belong to the age group 6-24 mo. while severe stunting was seen among 16,4% of the controls and nearly similar proportion in the three age groups. MUAC < 11.5 cm among the cases was 46.0%, 20.4%, and 1.3% in the three age groups respectively, while among the controls was 24.6%, 13.1%, and 11.5% in the three age groups respectively. A statistically significant age group difference between the cases and the controls, p-value is < 0.001.
Variable
Cases (No. 313)
Controls (No. 122)
p-valueᶳ
Mean
Std. Deviation
Mean
Std.
Deviation
13.04
7.34
20.05
12.93
< 0.001
5.41
1.33
7.05
1.74
< 0.001
68.32
7.1
76.89
10.46
< 0.001
10.57
1.36
11.28
1.11
< 0.001
Age group (month)
WFL/H
L/HFA
WFL/H
L/HFA
185 (59.1)
79 (25.2)
144 (46.0)
42 (34.4)
8 (6.6)
30 (24.6)
107 (34.2)
44 (14.1)
64 (20.4)
43 (35.2)
6 (4.9)
16 (13.1)
13 (4.2)
8 (2.6)
4 (1.3)
33 (27.1)
6 (4.9)
14 (11.5)
305 (97.5)
131 (41.9)
212 (67.7)
118 (96.7)
20 (16.4)
60 (49.2)
Discussion
In the present case control study, complicated severely wasted children admitted to inpatient care were younger, had significantly low mean weight, height, and MUAC compared to uncomplicated severely wasted children admitted to outpatient care. It was observed that WFL/H <- 3SD z-score group of severity seen more among the control; cases vs controls were (37.0% vs 68.9%). Howevere, comparing the other groups of severity (< - 4SD, < - 5SD, and < - 6SD z-scores), it was found that the proportion of these groups of severity among the cases were nearly more than twice the proportion in the controls. In addition, there were no children in control group with WFL/H <- 7SD z-score. A similar hospital based case control study was done in Rajasthan, India showed that < - 3SD z-score among the cases vs the controls was (26.0% vs 32.0%), < - 4SD cases vs controls was (27.0% vs 28.0%), and the proportion of < - 5 SD and < - 6SD group of severity was high among the cases vs the controls. No children among the controls belong to the groups < - 7SD and < - 8SD In our TFP, the majority of children admitted for severe wasting by WFL/H < - 3SD z-score criterion, not by MUAC criterion, and nearly similar proportion was found in the TFC and OTP (97.5%) and (96.7%) respectively. Similar finding was seen in a multicounty study done in India where the proportion of total children diagnosed as SAM by WFL/H z-score were significantly high (84.5%), compared to MUAC criterion MUAC < -11.5 cm was simultaneously found among (67.7%) of the cases that were identified as severe wasting by WFL/H, compared to (49.2%) among the controls. However, only (2.6%) and (3.3%) of children were admitted for severe wasting by only MUAC < 11.5 cm criterion in the cases and controls, respectively. If < 11.5 cm MUAC is used as a stand alone criterion in our TFP, then a large number of severely wasted children will remain undetected. MUAC becomes an essential tool, as it is a quick, easy and cheap method to identify acutely malnourished children in low-income, high-prevalence or emergency settings where resources may be limited. In addition, MUAC is primarily used to produce rapid prevalence estimates, and for community screening via Community-based Management of Acute Malnutrition (CMAM). Moreover, global evidence suggests that MUAC identifies children who are at a higher risk of mortality and require immediate care Significant proportion of cases were also stunted compared to the controls (41.9% vs 16.4%) and the majority of the cases were 6-24 mo. age group compared to the control (39.3% vs 11.5%). The proportion of stunting among our cases was higher than the proportion among complicated SAM found in a hospital based studies done in Egypt and Western Kenya, 23.2% and 23.0%, respectively
Conclusion
Children admitted to TFC had severe anthropometric deterioration at a younger age, evident not only by severe wasting of all grades that may be reaching up to < - 6, 7 SD as per WHO SD z score classification, but also chronic malnutrition which carries a high mortality risk, indicated by simultaneous presence of severe stunting and low MUAC. We recommend strengthening the active case finding of acute malnutrition in the community by assessing WFL/H criterion in addition to MUAC measurement for early detection and management of acute malnutrition. In addition, we recommend other TFPs in the neighboring governorates to conduct similar study to guide our policy makers for best practice with an overall aim to prevent undernutrition.