Gerhard Meissner

Gerhard Meissner is affiliated with the University of North Carolina, Chapel Hill, NC, United States. His research has focused on the structure and function of ryanodine receptor ion channels in skeletal and cardiac muscle, investigating channel gating mechanisms, regulatory domains, and modulation by calmodulin, nitric oxide, and redox-sensitive cysteines. His work has elucidated the roles of pore lining residues, cytosolic vestibule charges, and lumenal loops in determining ion channel conductance and activity, as well as the coupling of oxygen sensing and nitric oxide signaling functions in skeletal muscle calcium release channels. His most-cited publication, "The structural basis of ryanodine receptor ion channel function" (2017), has been cited 208 times and represents a significant contribution to understanding these critical calcium signaling complexes.